Re: A223 & A823 Question
Posted: Sat, 2022-Aug-20 5:25 pm
Fred,
To answer your immediate question, AFAIK, ONLY Nebula Genomics WGS tests have the potential of being imported into the FTD database. However, this has been promised for at least 2 years now and nothing has come of it so far.
(FYI, speaking of the rapid evolution in DNA testing technology, you want to look at YSEQ's WGS+ (30X) test and NOT their WGS400 (15X) test now. YFull has seen some issues with the read depths of the WGS400 tests, but the newer WGS+ tests have been good so far. Even YSEQ says that the WGS400 test is only for men who have already done a WGS+ test but need/want to refine results in problematic regions.)
But, every analyst of Y-DNA data brings their own subjective experience into the interpretation of the test results, so what FTD finds versus what YFull finds is never identical. And TBH, as far as I am concerned, Alex Williamson does the best analysis for free on his The Big Tree website. However updates to The Big Tree have drastically slowed down; although whether this is due to Alex's stated intention to slow down, or a slow down in data posted to the YDNA Warehouse, IDK.
However, the big news for Y-DNA testing came in March 2022 with the announcement by the T2T Consortium that they completely sequenced the entire Y chromosome of one man WITHOUT gaps, instead of the ~half of the Y chromosome that current tests sequence WITH gaps. That means that EVERY bp on the Y chromosome was sequenced and EVERY mutation was discovered. This was by no means an inexpensive process, but hopefully in the near future it can be done for under US$1000. Then, every man's Y-DNA sequence can be compared side-by-side, and ALL differences can be found. This will meld STR and SNP data together as well.
I expect we will see some basic Y-Haplotree reorganization when this T2T gapless type of testing becomes commercially available.
To answer your immediate question, AFAIK, ONLY Nebula Genomics WGS tests have the potential of being imported into the FTD database. However, this has been promised for at least 2 years now and nothing has come of it so far.
Nebula Genomics does do direct data sharing with YFull, as does YSEQ. YFull has data statistics on the various tests they process and it appears that on average a BigY 700 test covers ~18 Mbp, while most 30X WGS tests cover ~23Mbp. So that is an additional ~5Mbp of coverage, which means more SNPs are likely to be discovered. We have a Dál Cuinn Group project on the YFull website. AFAIK, this is the only other website besides the YDNA Warehouse, where you can preserve your test results; although you have to pay the FTD BAM file "tax" of US$99 to be able to transfer your BAM file data from FTD to one of the other sites.February 18, 2020
...However, there’s more news. Nebula has partnered with Family Tree DNA.
Hey, Family Tree DNA has a world-class lab, GenebyGene. Perhaps Nebula can move their processing there. I would even pay more to *NOT* send my DNA to a Chinese firm.
Beginning in Q2, you’ll be able to transfer at least some of your information from Nebula Genomics to Family Tree DNA’s Y and mitochondrial databases. This appears to be a direct company to company transfer, much easier than a download/upload, assures accuracy and provides enhanced security...
[ https://dna-explained.com/2020/02/18/ne ... -schedule/ ]
(FYI, speaking of the rapid evolution in DNA testing technology, you want to look at YSEQ's WGS+ (30X) test and NOT their WGS400 (15X) test now. YFull has seen some issues with the read depths of the WGS400 tests, but the newer WGS+ tests have been good so far. Even YSEQ says that the WGS400 test is only for men who have already done a WGS+ test but need/want to refine results in problematic regions.)
But, every analyst of Y-DNA data brings their own subjective experience into the interpretation of the test results, so what FTD finds versus what YFull finds is never identical. And TBH, as far as I am concerned, Alex Williamson does the best analysis for free on his The Big Tree website. However updates to The Big Tree have drastically slowed down; although whether this is due to Alex's stated intention to slow down, or a slow down in data posted to the YDNA Warehouse, IDK.
However, the big news for Y-DNA testing came in March 2022 with the announcement by the T2T Consortium that they completely sequenced the entire Y chromosome of one man WITHOUT gaps, instead of the ~half of the Y chromosome that current tests sequence WITH gaps. That means that EVERY bp on the Y chromosome was sequenced and EVERY mutation was discovered. This was by no means an inexpensive process, but hopefully in the near future it can be done for under US$1000. Then, every man's Y-DNA sequence can be compared side-by-side, and ALL differences can be found. This will meld STR and SNP data together as well.
I expect we will see some basic Y-Haplotree reorganization when this T2T gapless type of testing becomes commercially available.