...............................................YSEQ has just recently begun offering a new WGS test called the WGS400 for US$399 which is an excellent product. It provides a complete genome sequencing, which means it covers ALL of your chromosomes, not just the Y chromosome. You also get your mitochondrial and autosomal DNA sequenced, as well as medically relevant genes. YSEQ does not perform the analysis on the sequenced data, but there are other companies that will allow you to import sequenced data from testing labs like YSEQ for the analysis.
It also offers a more complete coverage of the Y chromosome than most NGS tests like the FTDNA BigY 700 test. Further, most NGS tests chop up the the Y chromosome into 100 or 150 nucleotide (bp - base pairs) long segments. After they analyze all of these segments, they have to glue everything back together in the correct order. There are parts of the Y chromosome that cannot be reassembled correctly because the 100 to 150 bp segments are just too short to be distinguished from each other. This new WGS400 product utilizes a "long read" process that only chops the Y chromosome into 400 bp long segments. This makes reassembly much more likely to be accurate.
I am waiting to hear back from YSEQ on which lab they are using for the sequencing; whether it is their German partner they are currently using for their 3 other WGS tests or if it is a new lab. I also want to find out how this test compares to their 30X WGS test at US$949 for detailed SNP/INDEL/SUB mutation testing. But all in all this is an exciting new product that should be carefully considered over wasting money on older, more expensive NGS tests.
